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High Resolution Image Download MS PowerPoint Slide A convenient and simple three-component synthesis of substituted pyridylacetic acid derivatives is reported. The approach centers on the dual reactivity of Meldrum’s acid derivatives, initially as nucleophiles to perform substitution on activated pyridine- N -oxides, then as electrophiles with a range of nucleophiles to trigger ring-opening and decarboxylation.
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Johnson et al. (2022) studied this question.
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