Key result
Combined IL-7Rα and pre-BCR deficiency in mice severely depletes pre-BII and peripheral B cells.
Why the study?
The in vivo relationship between the pre-BCR and the IL-7Ralpha in pre-BII cell expansion had not been previously examined.
Population
Mice lacking both pre-BCR and IL-7Ralpha receptors
Comparison
Mice lacking both receptors vs mice lacking only pre-BCR or only IL-7Ralpha
Design
Preclinical genetic deletion study
Authors
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Supports dual receptor requirement for murine pre-BII expansion; leaves open human translational relevance.
Both IL-7Ralpha and pre-BCR are required for optimal pre-BII cell expansion in vivo, and pre-BCR does not mediate IL-7Ralpha down-regulation.
Erlandsson et al. (2005) studied B cell development. Deficiency in both pre-BCR and IL-7Rα vs. Wild-type or single receptor deficiency was evaluated on pre-BII cell population expansion. Deficiency in both IL-7Rα and pre-BCR receptors in mice results in a severe reduction of the pre-BII cell population and depletion of the peripheral B cell pool.
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