Key result
Logan reference tissue method correlates linearly with arterial input method for binding potential in monkeys.
Why the study?
Does the Logan reference tissue method using the cerebellum accurately quantify mAChR binding of [11C]+3-MPB compared to the arterial input method in conscious monkeys?
Does the Logan reference tissue method using the cerebellum accurately quantify mAChR binding of [11C]+3-MPB compared to the arterial input method in conscious monkeys?
The cerebellum is a suitable reference region for quantification of mAChR in the living brain with [11C]+3-MPB and PET without the need for arterial blood sampling.
Supports non-invasive mAChR quantification in primate PET; leaves open human translation before clinical adoption.
N-[¹¹C]methyl-3-piperidyl benzilate ([¹¹C]+3-MPB) was developed as a positron emission tomography (PET) ligand for muscarinic cholinergic receptor (mAChR). The aim of the present study was to validate a Logan reference tissue method as an analytical method for in vivo binding of [¹¹C]+3-MPB to mAChR. Seven monkeys (Macaca mulatta) underwent [¹¹C]+3-MPB PET scans with an arterial blood sampling. Logan plot with arterial input function (Logan arterial input method) was performed to determine the binding potential (BP(ND)). The BP(ND) was also determined by Logan plot with the cerebellum as the reference region (Logan reference tissue method). BP(ND) values determined by Logan arterial input method and Logan reference tissue method showed a significant linear relationship. The present study suggests that the cerebellum is a suitable reference region for quantification of mAChR in the living brain with [¹¹C]+3-MPB and PET.
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Yamamoto et al. (2010) studied this question. Logan reference tissue method vs. Logan arterial input method was evaluated on Binding potential (BP(ND)) linear relationship. Binding potential values determined by the Logan reference tissue method using the cerebellum showed a significant linear relationship with the Logan arterial input method in conscious monkeys.
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