Chronic renal failure associated with topical application of paraphenylenediamineParaphenylenediamine ("para"), a derivative of paranitroaniline, is widely used as a hair dye.It has several toxic effects, ofwhich asthma and dermatitis are common.About 4% ofapparently normal subjects are sensitive to it, and 1% are acutely sensitive.'We report two cases of vasculitis and crescentic glomerulonephritis after prolonged topical application.
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Brown et al. (1987) studied this question.
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