Measures for the Core Outcome Set for Research Evaluating Interventions to Prevent and/or Treat Delirium in Critically Ill Adults: An International Consensus Study (Del-COrS)

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An international consensus panel recommends the CAM-ICU or ICDSC for measuring delirium occurrence, the HADS for emotional distress, and the MoCA-Blind for cognition in critical care delirium trials, while highlighting a lack of consensus for measuring health-related quality of life and post-traumatic stress. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Louise Rose; Bronagh Blackwood; Dale M. Needham; John W. Devlin; Mike Clarke; Lisa Burry

doi:10.1097/cce.0000000000000884

April 1, 2023Critical Care ExplorationsOpen Access

Measures for the Core Outcome Set for Research Evaluating Interventions to Prevent and/or Treat Delirium in Critically Ill Adults: An International Consensus Study (Del-COrS)

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Key Points

To establish international consensus on measurement instruments and assessment timeframes for a core outcome set used in clinical trials evaluating delirium prevention and treatment in critically ill adults.
Conducted an international consensus process across three virtual meetings in April 2021 with 18 stakeholders (clinicians, researchers, and 28% ICU survivors/family members) from six countries.
Participants reviewed instruments selected for validity, existing recommendations, and feasibility, voting on measures and time horizons using an a priori consensus threshold of ≥ 70%.
Consensus (≥ 70%) was reached for CAM-ICU or ICDSC to measure delirium occurrence and resolution (100%), HADS for emotional distress (71%), and MoCA-Blind for cognition (83%), with agreement to measure emotional distress and cognition up to 12 months post-discharge.
Consensus was not achieved for EQ-5D-5L for quality of life (69%), IES-R/IES-6 for post-traumatic stress (65%), or instruments assessing delirium severity with delirium-related emotional distress.
Stakeholders failed to reach consensus on exact timing for initiating or stopping delirium assessments or when to evaluate mortality.

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Implication

Consensus study identifies standard outcome measurement tools for delirium trials in critically ill adults, highlighting persistent gaps in severity and timing protocols.

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Rose et al. (2023) studied this question.

synapsesocial.com/papers/6aa95affd0c7c778ac8cd00b https://doi.org/10.1097/cce.0000000000000884

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Measures for the Core Outcome Set for Research Evaluating Interventions to Prevent and/or Treat Delirium in Critically Ill Adults: An International Consensus Study (Del-COrS)

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Cite This Study

Measures for the Core Outcome Set for Research Evaluating Interventions to Prevent and/or Treat Delirium in Critically Ill Adults: An International Consensus Study (Del-COrS)

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Implication

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