Key result
Norepinephrine remains first-line for shock but requires standardized dosing and titration practices.
Why the study?
Despite the ubiquitous use of norepinephrine as the first-line vasopressor for shock, clinical practice regarding its administration remains heterogeneous.
Design
Practical review article
Authors
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Should not yet change shock protocols; leaves open need for prospective validation of norepinephrine strategies.
This review provides practical guidance on the fundamentals of norepinephrine administration in critically ill patients with shock.
Kattan et al. (2024) conducted an editorial in Shock. Norepinephrine was evaluated. Norepinephrine remains the first-line vasopressor for shock, but significant heterogeneity exists in its dosing, formulation, and titration targets, highlighting the need for standardized practices.
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