Key result
Higher fasting clusterin correlates with overweight, obesity, and markers of systemic inflammation.
Why the study?
Clusterin/apolipoprotein J has been suggested as a biomarker reflecting inflammation, but its relationship with adiposity and systemic inflammation in healthy adults was unclear.
Cross-Sectional (n=204)
No
Absolute Event Rate: 52.2% vs 44.4%
p-value: p=<0.001
Fasting plasma clusterin levels correlate with adiposity and systemic inflammation in healthy adults, suggesting it may serve as a surrogate biomarker for obesity-associated systemic meta-inflammation.
No takes yet. Share an insight, caveat, or question.
Clusterin associates with adiposity and inflammation in cross-sectional data; hypothesis-generating for biomarker utility, should not yet change practice.
Won et al. (2014) conducted a cross-sectional in Healthy adults (n=204). Overweight and obesity vs. Lean subjects was evaluated on Fasting plasma clusterin concentration (µg/mL) (p=<0.001). Fasting plasma clusterin concentrations were significantly higher in overweight and obese subjects compared to lean subjects (52.2 vs 44.4 µg/mL) and positively correlated with markers of adiposity and systemic inflammation.
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