Key result
Abdominal aortic aneurysm linked to ~42% greater risk of incident dementia.
Why the study?
Abdominal aortic aneurysm and dementia share similar epidemiological profiles and pathogenic mechanisms, but few studies have evaluated the link between these two diseases.
Does abdominal aortic aneurysm increase the risk of newly diagnosed dementia in adults?
Cohort (n=61,004)
Does abdominal aortic aneurysm increase the risk of newly diagnosed dementia in adults?
Adults with a new diagnosis of abdominal aortic aneurysm have a significantly higher risk of developing dementia, particularly vascular dementia, compared to matched controls.
Association between AAA and dementia is hypothesis-generating; leaves open causal link and any screening implications.
Background Abdominal aortic aneurysm (AAA) and dementia have similar epidemiological profiles and common pathogenic mechanisms. However, there have been few studies on the link between these two diseases.Materials and methods For this study, information from 2009 to 2015 was extracted from the Korean National Health Insurance system database. A total of 15,251 participants with a new diagnosis of AAA was included. Propensity score matching by age and sex with patients in whom AAA was not diagnosed was used to select the control group of 45,753 participants. The primary endpoint of this study was newly diagnosed dementia (Alzheimer’s disease (AD), vascular dementia (VD), or other type of dementia). ResultsThe incidence of dementia was 23.084 per 1000 person years in the AAA group, which was higher than that of the control group (15.438 per 1000 person years). When divided into AD and VD groups, the incidence of AD was higher than that of VD, but the HR of AAA for occurrence of dementia was higher in VD (1.382 vs. 1.784). Among the various risk factors, there was an interaction if age, hypertension, and history of cardiovascular disease with incidence of dementia (p < 0.05). In the presence of hypertension, the HR for occurrence of dementia was high according to presence or absence of AAA (1.474 vs 1.165). In addition, this study showed higher HR in the younger age group (age < 65) and in the group with no history of cardiovascular disease [1.659 vs. 1.403 (age), 1.521 vs. 1.255 (history of cardiovascular disease)].Conclusions AAA was associated with increased risk of dementia regardless of AD or VD, even after adjusting for several comorbidities. These findings indicate that follow-up with AAA patients is necessary for early detection of signs and symptoms of dementia.
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Cho et al. (2021) conducted a cohort in Abdominal aortic aneurysm (AAA) (n=61,004). Abdominal aortic aneurysm vs. Patients without abdominal aortic aneurysm was evaluated on Newly diagnosed dementia (Alzheimer's disease, vascular dementia, or other type) (HR 1.422, 95% CI 1.326-1.525, p=<0.001). Abdominal aortic aneurysm was associated with a significantly increased risk of incident dementia compared to matched controls (HR 1.422), even after adjusting for multiple comorbidities.
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