Key result
New AAA diagnosis linked to ~67% higher cardiovascular disease risk.
Why the study?
CVDs including MI and stroke are often diagnosed in patients with AAA, but little has been reported regarding their incidence.
Does the presence of an abdominal aortic aneurysm increase the risk of cardiovascular diseases and death in a matched population?
Cohort (n=43,288)
Does the presence of an abdominal aortic aneurysm increase the risk of cardiovascular diseases and death in a matched population?
Patients with abdominal aortic aneurysm have a significantly higher risk of developing cardiovascular diseases (myocardial infarction and stroke) and higher mortality compared to matched controls, highlighting the need for proactive primary prevention.
Cardiovascular diseases (CVDs) including myocardial infarction (MI) and stroke are often diagnosed in patients with abdominal aortic aneurysm (AAA). However, little has been reported regarding the incidence.Patients with AAA were selected from the National Health Insurance system in South Korea between 2009 and 2015. A total of 10,822 participants with a new diagnosis of AAA were included. Propensity score matching by age and sex with patients in whom AAA was not diagnosed was used to select the control group of 32,466 participants. Primary endpoints included the diagnosis of CVD and death. Cox proportional hazard models were used to compare the risk of disease incidence.The incidence of CVD was 16.573 per 1,000 person-years in the AAA group, which was higher than that of the control group's 9.30 per 1,000 person-years. The incidence of MI (hazard ratio [HR], 1.7; 95% confidence interval [CI], 1.479-1.953), stroke (HR, 1.629; 95% CI, 1.443-1.839), and CVD (HR, 1.672; 95% CI, 1.522-1.835) was significantly higher in patients with AAA. Mortality rate was also elevated in the AAA group (HR, 2.544; 95% CI, 2.377-2.722).The incidence of CVD was significantly more frequent in patients with AAA. The AAA group had consistently higher risks regarding CVD and mortality than the control group.
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Ko et al. (2021) conducted a cohort in Abdominal aortic aneurysm (n=43,288). Abdominal aortic aneurysm vs. Patients without abdominal aortic aneurysm was evaluated on Diagnosis of cardiovascular disease (HR 1.672, 95% CI 1.522-1.835). Patients with a new diagnosis of abdominal aortic aneurysm had a significantly higher incidence of cardiovascular disease compared to matched controls (16.57 vs 9.30 per 1,000 person-years; HR 1.672).
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