Key result
FTO rs9939609 A-allele linked to ~13% higher CRP levels independently of obesity.
Why the study?
Variation at the FTO gene locus has been reported to be associated with increased body fat, but its effect on CRP plasma levels was unclear.
Does the FTO rs9939609 T>A single nucleotide polymorphism alter C-reactive protein levels in a population-based sample?
Population
2,415 participants from a large prospective cohort study
Comparison
FTO rs9939609 T>A polymorphism A-allele carriers vs non-carriers
Design
Population-based prospective cohort study
Authors
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FTO A-allele links to higher CRP beyond obesity; hypothesis-generating for inflammation pathways, needs prospective validation before clinical use.
Cohort (n=2,415)
Does the FTO rs9939609 T>A single nucleotide polymorphism alter C-reactive protein levels in a population-based sample?
Effect estimate: +14% (men) and +12% (women) per A-allele
p-value: p=0.03 (men), 0.02 (women)
The FTO rs9939609 T>A polymorphism is associated with increased plasma CRP levels independently of obesity indices.
Fisher et al. (2008) reported a cohort. FTO rs9939609 T>A single nucleotide polymorphism (A-allele) was evaluated on C-reactive protein (CRP) plasma levels (+14% (men) and +12% (women) per A-allele, p=0.03 (men), 0.02 (women)). The FTO rs9939609 A-allele was significantly associated with increased plasma CRP levels independently of obesity indices (men: +14%, P=0.03; women: +12%, P=0.02 per A-allele).
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