Key result
Perindopril improves learning and memory in AD rats, reducing required escape trials by ~22%.
Why the study?
The pathological mechanisms of Alzheimer disease remain unclear, and the role of altered angiotensin-converting enzyme and ACE inhibitors in AD brain structure and function requires investigation.
Does perindopril improve learning and memory and reduce amyloid deposition in a rat model of Alzheimer disease?
Comparison
Perindopril treatment vs untreated AD model vs control
Design
Randomized preclinical study
Authors
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Hypothesis-generating for perindopril in Alzheimer disease; should not yet alter clinical practice.
Does perindopril improve learning and memory and reduce amyloid deposition in a rat model of Alzheimer disease?
Absolute Event Rate: 18.5% vs 23.7%
p-value: p=<0.001
In a rat model of Alzheimer's disease, the ACE inhibitor perindopril improved learning and memory and reduced amyloid deposition, suggesting a potential neuroprotective role.
Hou et al. (2008) studied Alzheimer disease (rat model) (n=60). Perindopril vs. AD group and control group was evaluated on Number of times needed to escape electrical stimuli (p=<0.001). Perindopril improved learning and memory in AD rats, decreasing the number of times needed to escape electrical stimuli compared to the AD group (18.50 vs 23.70, P<0.001).
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