Key result
Ambulatory prehypertension and hypertension in children are linked to accelerated vascular age versus normotensive peers.
Why the study?
Primary hypertension may lead to early vascular ageing, but differences between expected vascular age based on PWV/cIMT and chronological age in adolescents were uncharacterized.
Do adolescents with primary hypertension have accelerated vascular age compared to normotensive peers?
Cross-Sectional (n=416)
Do adolescents with primary hypertension have accelerated vascular age compared to normotensive peers?
Adolescents with ambulatory prehypertension and true hypertension exhibit accelerated vascular aging compared to normotensive peers, highlighting the early vascular impact of primary hypertension in youth.
May signal early vascular risk in pediatric prehypertension; leaves open whether screening or intervention alters long-term outcomes.
BACKGROUND: Primary hypertension may lead to early vascular ageing. We aimed to evaluate differences between expected vascular age based on pulse wave velocity (PWV)/carotid intima-media thickness (cIMT) and actual chronological age (CHA) in adolescents with primary hypertension. METHODS: Three hundred and fifty-two children (median age of 15.5 years) with office hypertension and 64 normotensive healthy children of the same age underwent anthropometry, office and ambulatory blood pressure (BP), left ventricular mass index, cIMT, PWV, pulse wave analysis and biochemistry measurements. Vascular age was calculated using pooled pediatric and adult normative PWV and cIMT data. The difference between vascular age and CHA was calculated in relation to the 90th percentile for PWV (PWVAgeDiff90) and the 95th percentile for cIMT (cIMTAgeDiff95). RESULTS: One hundred and sixty-six patients had white-coat hypertension (WCH), 32 had ambulatory prehypertension (AmbPreHT), 55 had isolated systolic hypertension with normal central SBP (ISH+cSBPn), 99 had elevated office, ambulatory and cSBP (true hypertension, tHT). The differences between vascular age (both PWV and cIMT based) and CHA were significantly higher in AmbPreHT and tHT compared with normotension, WCH and ISH+cSBPn. Median PWVAgeDidff90 was -3.2, -1.2, -2.1, +0.8 and +0.3 years in normotension, WCH, ISH+cSBPn, AmbPreHT and tHT, respectively. Median cIMTAgeDiff95 was -8.0, -6.3, -6.8, -3.8 and -4.3 years in normotension, WCH, ISH+cSBPn, AmbPreHT and tHT, respectively. Significant predictors of PWVAge90Diff were the DBP and serum cholesterol, whereas cSBP and augmentation index were significant predictors of cIMTAgeDiff95. CONCLUSION: Children with AmbPreHT and tHT show accelerated vascular age compared with their normotensive peers.
No takes yet. Share an insight, caveat, or question.
Obrycki et al. (2022) conducted a cross-sectional in Primary hypertension (n=416). Primary hypertension vs. Normotension was evaluated on Difference between vascular age (PWV and cIMT based) and chronological age. Children with ambulatory prehypertension and true hypertension showed accelerated vascular age compared with normotensive peers (median PWV age difference +0.8 and +0.3 vs -3.2 years).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: