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Experimental study demonstrates high enantioselectivity in ketone and aldehyde aminoxylation using recyclable proline, indicating sustainable organocatalytic synthesis.
Proline-catalyzed direct asymmetric α-aminoxylation of aldehydes and ketones in the room temperture ionic liuqid 1-n-butyl-3-methylimidazolium tetrafluoroborate achieved high yields and high enantioselectivities, even when just 1–5% of proline was used as the catalyst; immobilisation of the catalyst in an ionic liquid phase offers simple product isolation and the reuse of the catalytical system at least four times in subsequent reactions.
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Guo et al. (2006) studied this question.
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