Key result
Thrombolytic therapy linked to ~54% lower in-hospital mortality despite more deaths from cardiac rupture.
Why the study?
Does thrombolytic therapy affect the incidence and timing of cardiac rupture in patients with acute myocardial infarction?
Population
350,755 patients with acute myocardial infarction enrolled in the United States National Registry of…
Comparison
Thrombolytic therapy vs No thrombolytic therapy
Design
Cohort
Follow-up
In-hospital (up to 30 days)
Authors
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While thrombolytic therapy reduces overall in-hospital mortality in acute myocardial infarction, it is independently associated with an accelerated risk of early death from cardiac rupture.
Observational (n=350,755)
Yes
Does thrombolytic therapy affect the incidence and timing of cardiac rupture in patients with acute myocardial infarction?
Absolute Event Rate: 5.9% vs 12.9%
p-value: p=<0.001
While thrombolytic therapy reduces overall in-hospital mortality in acute myocardial infarction, it is independently associated with an accelerated risk of early death from cardiac rupture.
Becker et al. (1996) conducted an observational in acute myocardial infarction (n=350,755). Thrombolytic therapy vs. No thrombolytic therapy was evaluated on In-hospital mortality (p=<0.001). Thrombolytic therapy was associated with lower in-hospital mortality (5.9% vs 12.9%) but a higher proportion of deaths due to cardiac rupture (12.1% vs 6.1%, p<0.001).