Key result
Ischaemic heart disease is linked to elevated serum uric acid and hs-CRP versus healthy controls.
Why the study?
Uric acid and hs-CRP are implicated in vascular disease and inflammation, but their association in ischaemic heart disease patients was not well established.
Are serum uric acid and hs-CRP levels elevated and correlated in patients with ischaemic heart disease?
Case-Control (n=100)
No
Are serum uric acid and hs-CRP levels elevated and correlated in patients with ischaemic heart disease?
Absolute Event Rate: 6.86% vs 4.66%
p-value: p=<0.001
Serum uric acid and hs-CRP are significantly elevated in patients with ischaemic heart disease compared to healthy controls, suggesting a role in the pathophysiology of the disease, although their direct correlation was not statistically significant.
INTRODUCTION: Uric acid (UA) contributes to the development of human vascular disease and atherosclerosis through a pro-inflammatory pathway.Highly-sensitive Creactive protein (hs-CRP) also has emerged as the most exquisitely sensitive systemic marker of inflammation and a powerful predictive marker of future cardiovascular risk.In this study we estimated the levels of serum uric acid and hs-CRP in patients with ischaemic heart disease and association between them.METHODS: Study was carried out among fifty (50) newly diagnosed patients of ischaemic heart disease and fifty (50) age and sex matched healthy controls.Serum uric acid, hs-CRP, random glucose, urea, creatinine and cardiac troponin-I were measured. RESULTS:The mean serum uric acid level in the control group was 4.66 ± 0.97 mg/dl and in case group was 6.86 ± 0.90 mg/dl.Mean hs-CRP level in control group was 0.19 ± 0.09 mg/dl, in case group was 5.14 ± 2.11 mg/dl.There was a positive association between UA and hs-CRP but the correlation was statistically not significant (p > 0.05).CONCLUSION: Our study indicated that there was a statistically significant association between ischaemic heart disease patients and elevated serum UA and serum hs-CRP and hence a strong role in the pathophysiology of ischaemic heart disease.
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A 2012 study conducted a case-control in Ischaemic heart disease (n=100). Ischaemic heart disease vs. Healthy controls was evaluated on Serum uric acid level (mg/dl) (p=<0.001). Patients with ischaemic heart disease had significantly elevated serum uric acid (6.86 vs 4.66 mg/dl) and hs-CRP (5.14 vs 0.19 mg/dl) compared to healthy controls, though the two markers were not significantly correlated.
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