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April 2, 2013Current Opinion in Endocrinology Diabetes and Obesity

Recent advances in adrenocortical carcinoma in adults

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Key result

Recent advances in genetics, imaging, and therapies update the management of adult adrenocortical carcinoma.

Why the study?

Adrenocortical carcinoma is a rare and aggressive malignancy with poor 5-year survival and limited effective therapies, and large cohort studies were lacking until recent international collaborations.

Population

Adults with adrenocortical carcinoma

Comparison

Recent advances in genetic, hormonal evaluation, imaging, and therapies versus previous approaches

Design

Review of recent international and multicenter studies

Authors

IBIsabelle BourdeauCentre Hospitalier de l’Université de MontréalJMJessica MacKenzie-FederALAndré LacroixCentre Hospitalier de l’Université de Montréal

Discussion

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Implication

Collaborative ACC data refine risk stratification and multimodal care; leaves open prospective validation of biomarkers and targeted therapies.

Structured PICO

P
Population
Adults with adrenocortical carcinoma (ACC)
I
Intervention
Recent advances in genetic and hormonal evaluation, imaging (FDG-PET, metomidate), and therapies (surgery, mitotane, radiotherapy, chemotherapy)

This review summarizes recent advances in the diagnosis and management of adrenocortical carcinoma, highlighting new imaging modalities and therapeutic approaches.

Limitations

  • There is still an important need to understand the molecular mechanisms underlying this disease to design better therapeutic approaches.

Cite This Study

Bourdeau et al. (2013) conducted a review in Adrenocortical carcinoma. Recent collaborative studies and advances in genetics, imaging, and therapies provide new evidence-based insights for the management of adrenocortical carcinoma in adults.

synapsesocial.com/papers/6aa9de7f2cb60ec273f6a723https://doi.org/10.1097/med.0b013e3283602274
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diagnostic and Prognostic Value of 18-Fluorodeoxyglucose Positron Emission Tomography in Adrenocortical Carcinoma: A Prospective Comparison with Computed Tomography2006 · 170 citations
  2. 2[131I]Iodometomidate for Targeted Radionuclide Therapy of Advanced Adrenocortical Carcinoma2011 · 88 citations
  3. 3Treatment of Advanced Adrenocortical Carcinoma with Erlotinib plus Gemcitabine2008 · 148 citations
  4. 4Use of [18F]Fluorodeoxyglucose Positron Emission Tomography in Evaluating Locally Recurrent and Metastatic Adrenocortical Carcinoma2006 · 116 citations
  5. 5Genetic aspects of adrenocortical tumours and hyperplasias2012 · 47 citations