Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 25, 2023Israel Journal of Health Policy ResearchOpen Access

Cytomegalovirus (CMV) seroprevalence among women at childbearing age, maternal and congenital CMV infection: policy implications of a descriptive, retrospective, community-based study

View Full Paper
Ask AI
Bookmark
Share

Key result

Pre-pregnancy CMV seropositivity is linked to a ~98% lower rate of maternal CMV infection versus seronegativity.

  • P<0.001
  • n=45,634

Why the study?

Although guidelines recommend against it, CMV screening during pregnancy is prevalent in Israel, prompting the need for updated epidemiological data and evaluation of CMV serology testing yield.

Population

45,634 women at childbearing age with 84,110 gestational events in Jerusalem

Comparison

Initially seropositive vs seronegative women

Design

Descriptive, retrospective, community-based study

Authors

ASAssaf Ben ShohamClalit Health ServicesYSYechiel SchlesingerHebrew University of JerusalemIMIan MiskinHebrew University of Jerusalem

Discussion

Loading...

Member takes

Implication

May limit repeat CMV serology in seropositive women; leaves open congenital CMV prevention strategies.

Study Design

Type

Observational (n=45,634)

Multicenter

No

Structured PICO

P
Population
45,634 women of childbearing age (18-44 years) with at least one gestational outcome between 2013 and 2019, followed to assess CMV seroprevalence and infection rates.
E
Exposure
Serial CMV serology testing
O
Outcome
CMV seroprevalence, incidence of maternal CMV infection during pregnancy, and prevalence of congenital CMV (cCMV)

Main Result

Absolute Event Rate: 0.2% vs 10.3%

p-value: p=<0.001

Routine CMV serology testing among women who were seropositive in a prior test has no clinical value for detecting non-primary infections that lead to congenital CMV.

Limitations

  • Retrospective design with variation in the frequency of serology testing
  • Lack of clinical data to differentiate between recurrent infection or reactivation
  • Lack of universal cCMV screening for all newborns, leading to underestimation of cCMV prevalence
  • Lack of data regarding the exact date of conception, potentially overestimating infections during pregnancy

Cite This Study

Shoham et al. (2023) conducted an observational in Cytomegalovirus (CMV) infection in pregnancy (n=45,634). Pre-pregnancy CMV seropositivity vs. Pre-pregnancy CMV seronegativity was evaluated on CMV infection in pregnancy (p=<0.001). Pre-pregnancy CMV seropositivity was associated with a significantly lower rate of CMV infection during pregnancy compared to seronegativity (0.2% vs 10.3%).

synapsesocial.com/papers/6aa9e25a52cffb64cd35daa2https://doi.org/10.1186/s13584-023-00566-9
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Risk of cytomegalovirus‐associated sequelae in relation to time of infection and findings on prenatal imaging2013 · 131 citations
  2. 2The apparent paradox of maternal seropositivity as a risk factor for congenital cytomegalovirus infection: a population‐based prediction model2013 · 197 citations
  3. 3Congenital Cytomegalovirus Infection1982 · 693 citations
  4. 4Ethical and Public Health Implications of Targeted Screening for Congenital Cytomegalovirus2020 · 39 citations
  5. 5A systematic literature review of the global seroprevalence of cytomegalovirus: possible implications for treatment, screening, and vaccine development2022 · 235 citations