Key result
Single-dose chaetochromin induces slow-developing myocardial, liver, and bone marrow necrosis in mice.
Why the study?
The toxic effects and organ-specific lesions caused by a single sublethal dose of chaetochromin in mice were not fully characterized.
Chaetochromin, a mycotoxin, induces significant myocardial and hepatic necrosis as well as bone marrow suppression in mice.
Answers are grounded in this paper and cite their sources.
Raises possibility of mycotoxin-related myocardial and marrow toxicity; leaves open human translation and requires validation.
A sublethal dose of 140mg/kg b.w. of chaetochromin, a mycotoxin produced by Chaetomium spp, caused lesions in various organs characterized by rather slow-developing necrosis and repair in the ICR male mice. With 3 to 4 days of latent period, focal necrosis of the liver and myocardium and diffuse hematopoietic cell necrosis of the bone marrow were observed histologically. Necrosis also occurred in the spleen, lymph nodes, and thymus but intestinal epithelial cells were not affected. Electron microscopic examination of the heart revealed mitochondrial swelling and degeneration showing myelin-like figures at 3 days, focal and single cell necrosis with disruption of myofibrils at 7 or 8 days. After 11 days calcification developed in necrotic foci of the heart and liver, ensuing foreign body reaction up to 24 days. The bone marrow recovered with no sequelae by 14 to 24 days.
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Kohichiro Ohtsubo (1989) studied Mycotoxin toxicity (n=42). Chaetochromin vs. Control was evaluated on Histological lesions in liver, myocardium, and bone marrow. A single oral dose of 140 mg/kg chaetochromin in mice induced slow-developing focal necrosis of the liver and myocardium, and diffuse hematopoietic cell necrosis of the bone marrow.
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