Key result
Doxycycline therapy resolves Mycoplasma pneumonia and drops Pelger-Huet cell count to 0%.
Why the study?
The occurrence of acquired Pelger-Huet anomaly in association with Mycoplasma pneumoniae pneumonia was not previously well documented.
Case Report (n=1)
Acquired Pelger-Huet anomaly can be associated with Mycoplasma pneumoniae pneumonia and resolves with appropriate antibiotic therapy.
Answers are grounded in this paper and cite their sources.
May prompt consideration of acquired Pelger-Huët anomaly in Mycoplasma pneumoniae; single case leaves open causal confirmation and generalizability.
A case report of a healthy 33-year-old man with Mycoplasma pneumoniae pneumonia who concomitantly had the acquired Pelger-Huet anomaly develop is presented. Up to 31% of his total white blood cell count was comprised of Pelger-Huet cells at the height of his clinical illness. The Pelger-Huet cell count returned to 0% after doxycycline therapy and resolution of the pneumonia. No other explanation for the Pelger-Huet anomaly could be determined. A review of the pertinent hematologic literature is included.
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Hook et al. (1985) conducted a case report in Mycoplasma pneumoniae pneumonia with acquired Pelger-Huet anomaly (n=1). Doxycycline therapy was evaluated on Pelger-Huet cell count. Doxycycline therapy and resolution of Mycoplasma pneumoniae pneumonia resulted in the Pelger-Huet cell count returning from 31% to 0%.
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