Key result
Denervation-induced skeletal muscle atrophy is linked to increased mTOR activation but decreased ribosomal RNA synthesis.
Population
Denervated atrophic skeletal muscle model
Design
Preclinical
Follow-up
2 weeks
Authors
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Should not change clinical management of atrophy; leaves open TAFIa as regulator of ribosome biogenesis beyond mTOR.
In denervated atrophic muscle, ribosome biogenesis is strongly controlled by factors other than the mTOR pathway, potentially limited by decreased TAFIa expression.
Machida et al. (2011) studied Skeletal muscle atrophy. Denervation vs. Innervated muscle was evaluated on Skeletal muscle mass, mTOR pathway activation, and ribosome biogenesis. Denervation-induced skeletal muscle atrophy was associated with increased mTOR pathway activation but dramatically decreased de novo ribosomal RNA synthesis, potentially limited by decreased TAFIa.
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