Key result
Hyponatremia is linked to a ~108% higher risk of femoral neck fracture.
Why the study?
The prevalence of hyponatremia in patients with intracapsular femoral neck fractures was not well characterized.
Is hyponatremia associated with an increased risk of intracapsular femoral neck fractures?
Case-Control (n=1,243)
No
Is hyponatremia associated with an increased risk of intracapsular femoral neck fractures?
Odds Ratio: 2.08
Absolute Event Rate: 19.5% vs 10.4%
p-value: p=<0.001
Hyponatremia is significantly associated with femoral neck fractures, suggesting serum sodium should be regularly assessed and corrected in at-risk populations.
Hyponatremia was associated with femoral neck fracture; supports screening in elderly fallers but leaves causal role and correction benefit open.
This study was aimed at investigating the prevalence of hyponatremia in patients with intracapsular femoral neck fracture. All records containing clinical and laboratory information of patients admitted with femoral neck fractures to the Academic Hospital of Parma (Italy) during the year 2013 were retrieved from the hospital database. The control population consisted of subjects admitted to the outpatient phlebotomy center during the same period. The final population consisted of 543 patients with femoral neck fractures and 700 outpatients. The category of elderly subjects (i.e., ≥65 years) included 491 patients and 380 controls. In both the entire population and elderly subjects, serum sodium was lower in patients than in controls (138 versus 139 mmol/L, P < 0.001). The prevalence of hyponatremia was also higher in cases than in controls, both in the entire population (19.5 versus 10.4%, P < 0.001) and in elderly subjects (20.8 versus 11.8%, P < 0.001). The odds ratio of hyponatremia for femoral neck fracture was 2.08 in the entire study population and 1.95 in those aged 65 years and older. In conclusion, we found that hyponatremia is significantly associated with femoral neck fracture. Serum sodium should hence be regularly assessed and hyponatremia eventually corrected.
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Cervellin et al. (2014) conducted a case-control in Femoral neck fracture (n=1,243). Hyponatremia vs. Normonatremia was evaluated on Prevalence of hyponatremia (OR 2.08, p=<0.001). Hyponatremia was significantly associated with femoral neck fracture, present in 19.5% of fracture patients versus 10.4% of outpatient controls (OR 2.08; P<0.001).
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