Key result
Numerous animal models capture specific osteomyelitis aspects but none fully encompass acute and chronic disease.
Why the study?
Because of the variety in disease presentations and pathophysiology of osteomyelitis, it is very difficult to evaluate in clinical studies, necessitating the creation of animal models for in vivo experimentation.
This review provides an overview of various animal models available for studying acute and chronic osteomyelitis, emphasizing the need for careful model selection based on specific research goals.
Requires careful model selection for osteomyelitis research; leaves open a comprehensive model for acute and chronic disease.
Osteomyelitis is an acute or chronic inflammatory process of the bone and its related structures secondary to an infection with pyogenic organisms. Because of the variety in disease presentations and pathophysiology of osteomyelitis, it is very difficult to evaluate in clinical studies. Therefore, animal models have been created for in vivo experimentation. A PubMed and OVID search was performed on March 31, 2008, using keywords osteomyelitis, animal model (rabbit, rat, mouse, avian, dog, sheep, and goat), and experimental osteomyelitis. The objective of this review was to provide a literature review of the animal models created to study osteomyelitis. The models were chosen based on historical relevance and clinical applicability. Numerous animal models exist to study both acute and chronic osteomyelitis. Many models have been created that allow investigators to study various aspects in the treatment and diagnosis of osteomyelitis. Based on the needs of investigators, an animal model must be carefully selected for ideal research, as no single model encompasses all aspects of osteomyelitis.
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Patel et al. (2009) conducted a review in Osteomyelitis. Animal models was evaluated. Animal models for osteomyelitis are numerous and allow study of various aspects of the disease, though no single model encompasses all aspects of acute and chronic osteomyelitis.
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