Key result
11C-methionine PET detects ~127% greater tracer accumulation in the infarct territory 3 days post-MI.
Why the study?
Does (11)C-methionine PET imaging detect tissue inflammation early after myocardial infarction in experimental models and humans?
Population
In vitro macrophages, C57Bl/6 mice undergoing coronary artery ligation or no surgery, and a patient 3 days…
Comparison
C-methionine positron emission tomography imaging vs Healthy mice and remote healthy myocardium
Design
Preclinical
Follow-up
7 days
Authors
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May support (11)C-methionine PET for early post-MI inflammation imaging in models; leaves open human translation.
Does (11)C-methionine PET imaging detect tissue inflammation early after myocardial infarction in experimental models and humans?
Absolute Event Rate: 5.9% vs 2.6%
p-value: p=<0.01
(11)C-methionine PET imaging can successfully demarcate tissue inflammation early after myocardial infarction by targeting elevated amino acid metabolism in pro-inflammatory macrophages.
Thackeray et al. (2016) studied Myocardial infarction (n=28). 11C-methionine PET imaging vs. Healthy mice / remote myocardium was evaluated on 11C-methionine accumulation in the infarct territory at 3 days post-MI (%ID/g) (p=<0.01). 11C-methionine PET imaging detected significantly increased tracer accumulation in the infarct territory at 3 days post-myocardial infarction compared to healthy myocardium.
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