Key result
Multidisciplinary family screening and genetic testing enable preventive strategies to reduce SCD in high-risk relatives.
Why the study?
Sudden cardiac death in the young is a tragic consequence of genetic cardiovascular disorders, motivating a review of its genetic basis and clinical care strategies for affected families.
Family screening and genetic testing are crucial for identifying high-risk relatives of young sudden cardiac death victims to initiate preventive strategies.
Review synthesizes genetic SCD causes and family screening; leaves open standardized protocols pending prospective data.
BACKGROUND: Sudden cardiac death (SCD) in the young is a rare but tragic consequence of a number of genetic cardiovascular disorders. The care of survivors of cardiac arrest and families affected by SCD seeks to prevent further SCD events through family screening. OBJECTIVE: The aim of this article is to review the genetic basis of SCD in the young and outline the clinical aspects of caring for families affected by SCD. DISCUSSION: Inherited cardiomyopathies and primary arrhythmia syndromes are important causes of SCD in young people. Over the past 30 years, there has been an explosion of knowledge regarding the underlying genetic mechanisms of these disorders and dramatic advances in genetic testing technologies. Family screening with thorough multidisciplinary clinical assessment and genetic testing allows for the initiation of preventive strategies in high-risk relatives and ultimately a reduction in SCD events.
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Isbister et al. (2019) conducted a review in Sudden cardiac death in the young. Genetic testing and family screening was evaluated. Family screening with thorough multidisciplinary clinical assessment and genetic testing allows for the initiation of preventive strategies in high-risk relatives to reduce sudden cardiac death events.
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