Key result
Obesity is linked to higher endometrial cancer and mortality risk, mitigated by weight loss and exercise.
Why the study?
Endometrial cancer incidence is increasing worldwide and obesity is a prominent risk factor, prompting an evaluation of the mechanisms linking obesity to its development and the role of combating excess adipose tissue in prevention.
Does obesity increase the risk of development and mortality in endometrial cancer?
Does obesity increase the risk of development and mortality in endometrial cancer?
Obesity is a critical risk factor for the development and poor prognosis of endometrial cancer, highlighting the importance of weight management and exercise in prevention.
Obesity management may aid endometrial cancer prevention; leaves open the need for prospective trials to guide practice.
Introduction and purpose: Endometrial cancer [EC] is the most common gynecological cancer in developed countries and its incidence is increasing worldwide. Obesity is a prominent risk factor associated with its incidence and progression. The aim of study: The article aims to provide a thorough explanation of the mechanisms through which obesity can contribute to the development of EC. Additionally, it emphasizes the crucial role of combating excess adipose tissue as a significant component of cancer prevention specifically targeting endometrial cancer. Material and method: The literature review applied standard criteria and focused on PubMed articles using keywords: Endometrial cancer, Obesity, Mortality, Prevention, Pathogenesis Description of the State of Knowledge: Obesity significantly impacts EC development and prognosis, particularly in Type I cases. It modifies adipose tissue metabolism, affecting the release of various substances linked to tumor growth and mortality risk.The relative risks escalate with increasing BMI. Following an EC diagnosis, higher BMI, especially ≥40, significantly associates with increased overall mortality risk. On a preventive front, exercise showcases its potential in reducing EC risk by moderating insulin and estrogen levels. Summary: These findings underscore the critical role of obesity in both EC development and prognosis, emphasizing the potential for preventive measures. Without proactive measures, the worldwide obesity epidemic will persist, exerting a substantial effect on EC occurrences.
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Kolano et al. (2024) conducted a review in Endometrial Cancer. Obesity vs. Normal weight was evaluated. Obesity significantly increases the risk of developing endometrial cancer and is associated with higher overall mortality, while weight loss and physical activity serve as important preventive measures.
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