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January 1, 2021Therapeutic Advances in Respiratory DiseaseOpen Access

Burden of pulmonary arterial hypertension in England: retrospective HES database analysis

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Key result

PAH incurs a heavy economic burden with ~3 annual hospital admissions per patient.

  • n=2,527

Why the study?

The clinical and economic burden of pulmonary arterial hypertension is poorly understood outside the United States.

Population

2527 adult patients with PAH in England

Design

Retrospective database study

Authors

FEFernando G. ExpostoAarhus UniversityRHRuben HermansIQVIA (United Kingdom)ANA. NordgrenIQVIA (United Kingdom)

Discussion

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Implication

PAH imposes heavy costs in England; leaves open whether targeted therapies can reduce admissions and should not yet change practice.

Study Design

Type

Cohort (n=2,527)

Multicenter

Yes

Structured PICO

P
Population
2,527 adult patients with pulmonary arterial hypertension in England, evaluated for healthcare resource utilization and costs between 2012 and 2018.
O
Outcome
Healthcare resource utilisation (HCRU) including inpatient admissions, outpatient visits and A&E attendances, and associated costs

Pulmonary arterial hypertension imposes a substantial economic and healthcare resource burden in England, driven primarily by inpatient admissions and outpatient visits.

Limitations

  • Associated costs did not include PAH-specific drugs on the High Cost Drugs list.

Cite This Study

Exposto et al. (2021) conducted a cohort in Pulmonary arterial hypertension (n=2,527). Pulmonary arterial hypertension was evaluated on Healthcare resource utilisation (HCRU) and associated costs. Pulmonary arterial hypertension in England incurred a heavy economic burden, with mean annual admission rates of 2.9 to 3.2 per patient and total costs of £43.2 million from 2013 to 2017.

synapsesocial.com/papers/6aa9ed9bf830d21e1935de39https://doi.org/10.1177/1753466621995040
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Treatment Patterns and Associated Health Care Costs Before and After Treatment Initiation Among Pulmonary Arterial Hypertension Patients in the United States2018 · 47 citations
  2. 2The economic burden of pulmonary arterial hypertension (PAH) in the US on payers and patients2014 · 110 citations
  3. 3Healthcare resource utilization and costs for patients with pulmonary arterial hypertension: real-world documentation of functional class2017 · 39 citations
  4. 4Characterizing the financial burden of pulmonary arterial hypertension within an integrated healthcare delivery system2013 · 13 citations
  5. 5Validation of claims‐based algorithms for pulmonary arterial hypertension2018 · 29 citations