Key result
Hypertensive T2D with CVD is linked to ~2-fold higher NF-κB gene expression versus healthy controls.
Why the study?
The study was conducted to determine whether there is a link between type 2 diabetes complications and the level of nuclear factor kappa B (NF-κB) overexpression.
Is NF-κB gene overexpression associated with the development of cardiovascular disease in patients with hypertensive type 2 diabetes?
Case-Control (n=90)
No
Is NF-κB gene overexpression associated with the development of cardiovascular disease in patients with hypertensive type 2 diabetes?
Effect estimate: Fold change 2.163
Absolute Event Rate: 2.163% vs 1%
p-value: p=<0.05
NF-κB gene overexpression is associated with cardiovascular disease in patients with hypertensive type 2 diabetes, suggesting its potential as a biomarker for early CVD development.
NF-κB overexpression was associated with CVD in hypertensive T2D; leaves open its value as a prognostic biomarker.
The purpose of this research is to see if there is a link between diabetes type 2 complications and the level of nuclear factor kappa B (NF-κB) overexpression. Ninety blood samples were collected from individuals and divided into three groups, each group involved thirty samples: the first group representing individuals with (hypertensive type 2 diabetes ) ,the second group representing (hypertensive type 2 diabeteswith cardiovascular diseases), and the last group was represented by a control group. mRNA was extracted from blood samples then converted to cDNA by using the (qPCR) technique. The outcomes revealed a significant increase (p<0.05) in expression of mRNANF-κB in both groups compared to the control group and this over- expression in hypertensive type 2 diabetes with cardiovascular diseases more than hypertensive type 2 diabetes. The NF-κB gene was studied in type 2 diabetes and cardiovascular disease in the current study, and it could be a novel target for early CVD therapy in the future.
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Mervat Kamil kadhim and Alaa Mohammad Hasson Al-Husseini (2022) conducted a case-control in Hypertensive Type 2 Diabetes and Cardiovascular Disease (n=90). Hypertensive type 2 diabetes with cardiovascular disease vs. Healthy controls was evaluated on NF-κB gene expression (fold change) (Fold change 2.163, p=<0.05). Patients with hypertensive type 2 diabetes and cardiovascular disease had a significant 2.163-fold increase in NF-κB gene expression compared to healthy controls (p<0.05).
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