Key result
Improved [18F]FDOPA synthesis methods deliver robust GMP-compliant production with high activity yield and lower costs.
Why the study?
Use of [18F]FDOPA has been hampered by complex synthesis methods and high production costs, prompting efforts to provide robust GMP compliant synthesis methods with high activity yield and molar activity.
Advancements in GMP-compliant synthesis methods have improved the production and availability of [18F]FDOPA for PET/CT imaging.
May increase [18F]FDOPA PET availability for clinicians; leaves open outcome validation in cardiovascular populations.
F]FDOPA has been hampered by complex synthesis methods and high production costs in the past, significant efforts have been undertaken to provide robust GMP compliant synthesis methods with high activity yield and molar activity.
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Stormezand et al. (2024) studied this question. [18F]FDOPA synthesis methods have been improved to be robust and GMP-compliant, overcoming past complexities and high costs to provide high activity yield and molar activity.
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