The solubility of folic acid in water was measured at pH values between 0 and 7 at the temperatures (298.15, 303.15, and 313.15) K using a standard shake and settle method with analysis by high-performance liquid chromatography (HPLC). A temperature and dissociation constant related solubility model was built to describe the folic acid solubility performance, and the experimental data matched the model well with a square of the multiple correlation coefficient ( R 2 ) of 0.9900.
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Wu et al. (2010) studied this question.
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