Key result
High PM2.5 exposure plus high genetic risk is linked to up to ~2-fold higher CV death.
Why the study?
Whether genetic susceptibility to cardiovascular diseases enhances vulnerability to adverse cardiovascular outcomes from air pollution was unknown.
Does the combination of high air pollution (PM2.5) exposure and high genetic risk increase the incidence of cardiovascular diseases and cardiovascular death in individuals without prior CVD?
Population
249,082 genetically unrelated White British participants without CVD from the UK Biobank cohort
Comparison
High ambient PM2.5 exposure and high genetic risk vs low PM2.5 exposure and low genetic risk
Design
Cohort study
Follow-up
Median 10.8 years
Authors
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The combination of high PM2.5 exposure and high genetic predisposition is associated with elevated risks of cardiovascular death and incident CVDs, highlighting the need for both population-level pollution reduction and individualized prevention.
Cohort (n=249,082)
Does the combination of high air pollution (PM2.5) exposure and high genetic risk increase the incidence of cardiovascular diseases and cardiovascular death in individuals without prior CVD?
Effect estimate: HR 1.73 to 2.12
The combination of high PM2.5 exposure and high genetic predisposition is associated with elevated risks of cardiovascular death and incident CVDs, highlighting the need for both population-level pollution reduction and individualized prevention.
Rhee et al. (2024) conducted a cohort in Healthy (without prior cardiovascular disease) (n=249,082). High PM2.5 exposure and high genetic predisposition to CVD vs. Low genetic risk and lower PM2.5 exposure was evaluated on Cardiovascular death (HR 1.73 to 2.12). The combination of high PM2.5 exposure and high genetic risk was associated with the highest risk of cardiovascular death (adjusted HRs ranging from 1.73 to 2.12).
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