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October 1, 2018Journal of the American College of CardiologyOpen Access

Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults

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Authors

MIMichael InouyeBaker Heart and Diabetes InstituteGAGad AbrahamBaker Heart and Diabetes InstituteCNChristopher P. NelsonUniversity of Leicester

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Overview

Population cohort study demonstrates genomic scores stratify coronary artery disease trajectories in 480,000 adults, suggesting genomic screening can enhance early-life risk assessment.

Key Points

  • To develop and validate a genomic risk score for stratifying individual risk trajectories of coronary artery disease.
  • Evaluated a newly developed genomic risk score using genetic and clinical data from 480,000 adults.
  • Compared genomic trajectory stratification against conventional cardiovascular risk assessment approaches.
  • The genomic score successfully stratified individuals into distinct coronary artery disease risk trajectories across adulthood.
  • Genomic risk assessment showed clear capacity to complement conventional clinical risk prediction, particularly for early-life screening.

Cite This Study

Inouye et al. (2018) studied this question.

synapsesocial.com/papers/69d576db62196bac97d9bcd2https://doi.org/10.1016/j.jacc.2018.07.079
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