Key result
TKTL1 overexpression promotes HNSCC tumor growth and proliferation via increased aerobic glycolysis and HIF1α stabilization.
Why the study?
Does TKTL1 overexpression promote tumorigenesis in head and neck squamous cell carcinoma through aerobic glycolysis and HIF1alpha stabilization?
Population
Human head and neck squamous cell carcinoma tumor samples and normal mucosas, HNSCC cell line panels, and…
Comparison
TKTL1 overexpression construct and… vs Normal mucosas and vehicle-expressing HNSCC cells
Design
Preclinical
Authors
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TKTL1 may be a candidate therapeutic target in HNSCC; hypothesis-generating from animal data and leaves open clinical translation.
Does TKTL1 overexpression promote tumorigenesis in head and neck squamous cell carcinoma through aerobic glycolysis and HIF1alpha stabilization?
TKTL1 is a novel candidate oncogene in HNSCC that promotes malignant phenotypes through altered glycolytic metabolism and HIF1alpha accumulation.
Sun et al. (2010) studied Head and neck squamous cell carcinoma (HNSCC). TKTL1 overexpression vs. Normal mucosas and vehicle-expressing HNSCC cells was evaluated on Cellular proliferation, tumor growth, and glycolytic metabolism. TKTL1 overexpression, driven by promoter hypomethylation, promotes HNSCC cellular proliferation and tumor growth through increased aerobic glycolysis and HIF1α stabilization.
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