Helicobacter pylori infection and long term proton pump inhibitor therapy

Should Helicobacter pylori infection be eradicated in patients requiring long term proton pump inhibitor therapy for gastro-oesophageal reflux disease? S hould Helicobacter pylori infection be eradicated in patients requiring maintenance proton pump inhibi-tor therapy for gastro-oesophageal reflux disease? This question has stimu-lated heated debate and contention over the past few years. The issue first came to prominence in 1996 when Kuipers et al published their study purporting to demonstrate that omeprazole acceler-ated the development of corpus atrophic