Key result
Sauchinone inhibits Ang II-induced VSMC proliferation and migration and suppresses ROS production and NOX activity.
Why the study?
Vascular remodelling driven by vascular smooth muscle cells is an important complication of hypertension, but the functional role of sauchinone in hypertension has not been investigated.
Does sauchinone inhibit angiotensin II-induced proliferation and migration in vascular smooth muscle cells?
Does sauchinone inhibit angiotensin II-induced proliferation and migration in vascular smooth muscle cells?
Sauchinone demonstrates potential as a protective agent against vascular remodeling in hypertension by inhibiting Ang II-induced VSMC proliferation and migration.
Sauchinone attenuates VSMC remodelling in preclinical hypertension models; hypothesis-generating and requires clinical validation.
Hypertension is a common type of cardiovascular disease that remains a major cause of death in the world. Vascular remodelling is an important complication of hypertension, and vascular smooth muscle cells (VSMCs) play a major role in vascular remodelling. Sauchinone is one of the active lignins which has been found to possess vascular protective effects. However, the functional role of sauchinone in hypertension has not been investigated. The aim of this study was to evaluate the role of sauchinone in the angiotensin II (Ang II)-induced vascular remodelling model in VSMCs. The results showed that treatment of sauchinone inhibited Ang II-induced VSMCs proliferation and migration in VSMCs. Sauchinone treatment suppressed the reactive oxygen species (ROS) production and NADPH oxidase (NOX) activity in Ang II-induced VSMCs. The inhibitory effects of Ang II on expressions of VSMCs phenotype markers including α-smooth muscle actin (α-SMA), calponin, osteopontin were mitigated by sauchinone treatment. Furthermore, sauchinone inhibited Ang II-induced over-activation of TGF-β1/Smad3 signalling pathway in VSMCs. Taken together, this study identified sauchinone as a potential agent for preventing vascular remodelling in hypertension.
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Wang et al. (2019) studied Hypertension and vascular remodelling. Sauchinone vs. Angiotensin II alone was evaluated on Angiotensin II-induced proliferation and migration of vascular smooth muscle cells. Sauchinone inhibited Angiotensin II-induced proliferation and migration in vascular smooth muscle cells, and suppressed ROS production and NOX activity.
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