Breaking the Itch–Scratch Cycle in Prurigo Nodularis

Prurigo nodularis is a chronic dermatologic condition that features intensely itchy, excoriated nodules on the extensor surfaces of the arms and legs and on the trunk. The disorder is most common in middle age or later, and it can be associated with multiple systemic conditions, including chronic kidney disease, type 2 diabetes, and human immunodeficiency virus infection.1 The hallmark of prurigo nodularis is unrelenting itch, which is greater in intensity, frequency, and effect on quality of life than itch associated with other chronic, pruritic skin diseases such as atopic dermatitis and psoriasis.2 At the Johns Hopkins Itch Clinic, my colleagues . . .