Hirsutism.

Several groups have attempted to investigate the effect of vasectomy on the endocrine function of the human testis.30-37 The results have been conflicting and difficult to interpret because the changes may have been due to alterations in the sensitivity of the assay.35Nevertheless, it does seem that hormone concentrations remain within the normal range after vasectomy, though seasonal variations seem to be lost.38 Clearly, then, we need to learn much more about the effect of vasectomy on seminiferous tubules.We need to know about the possibility of different forms of testicular change in different people, predisposing factors such as a history of orchitis or a personal or family history of autoimmune disease, and the relation between the formation of sperm granulomas and testicular changes in man.Most importantly, however, we need further studies to define the risk of testicular cancer after vasectomy and to identify causal factors.