Key result
Diabetic retinopathy is linked to increased platelet sensitivity to ADP and decreased PGI2 sensitivity.
Why the study?
Is platelet sensitivity to ADP and PGI2 altered in diabetic patients with retinopathy compared to those without retinopathy and healthy controls?
Observational (n=69)
No
Is platelet sensitivity to ADP and PGI2 altered in diabetic patients with retinopathy compared to those without retinopathy and healthy controls?
Absolute Event Rate: 0.9% vs 1.9%
p-value: p=<0.001
Diabetic patients with retinopathy exhibit increased platelet sensitivity to ADP and decreased sensitivity to PGI2, suggesting a pro-aggregatory state that may contribute to diabetic microangiopathy.
Altered platelet sensitivity may mark pro-aggregatory risk in diabetic retinopathy; leaves open causal role and need for prospective trials.
ONODERA, H., HIRATA, T., SUGAWARA, H., SUGAI, K., YODA, B., TOYOTA, T. and GOTO, Y. Platelet Sensitivity to Adenosine Diphosphate and to Prostacyclin in Diabetic Patients. Tohoku J. exp. Med., 1982, 137 (4), 423-428 - We studied the platelet sensitivity to adenosine diphosphate (ADP) and to prostacyclin (PGI2) in order to clarify the mechanism of the onset or development of diabetic retinopathy. The platelet sensitivity to ADP in diabetics with simple and proliferative retinopathy was significantly increased as compared with that in diabetics without retinopathy and in controls. The platelet sensitivity to PGI2 in diabetics with simple and proliferative retinopathy was decreased significantly as compared with the normal value. There was a significant negative correlation between the platelet sensitivity to ADP and that to PGI2 in all diabetics. Since the effect of PGI2 on platelets is to inhibit its aggregation, the decreased sensitivity to PGI2 implies a tendency to accelerate platelet aggregation. The increased platelet aggregation due to the alteration of the platelet sensitivity is considered as an important factor in diabetic microangiopathy. - diabetes mellitus; diabetic retinopathy; platelet sensitivity; prostacyclin (PGI2); adenosine diphosphate (ADP)
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Onodera et al. (1982) conducted an observational in Diabetes mellitus with and without retinopathy (n=69). Diabetic retinopathy vs. Healthy subjects was evaluated on Platelet sensitivity to ADP (concentration in µM required for half maximum aggregation) (p=<0.001). Diabetic patients with retinopathy showed significantly increased platelet sensitivity to ADP (0.9 µM vs 1.9 µM) and decreased sensitivity to PGI2 compared to healthy controls.
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