Key result
Cardiovascular Magnetic Resonance identified severe myocardial inflammation and concurrent left ventricular impairment in all 4 patients with Duchenne Muscular Dystrophy following mild COVID-19.
Why the study?
Does Cardiovascular Magnetic Resonance (CMR) identify post-COVID-19 myocarditis in asymptomatic patients with Duchenne Muscular Dystrophy?
Case Report (n=4)
Does Cardiovascular Magnetic Resonance (CMR) identify post-COVID-19 myocarditis in asymptomatic patients with Duchenne Muscular Dystrophy?
CMR demonstrates strong diagnostic value in identifying post-COVID-19 myocarditis in asymptomatic children with Duchenne Muscular Dystrophy.
Answers are grounded in this paper and cite their sources.
May support CMR for subclinical myocarditis detection in asymptomatic DMD children post-COVID; hypothesis-generating and requires prospective validation.
In this case series, we describe the diagnosis of post-COVID-19 myocarditis in asymptomatic patients with Duchenne Muscular Dystrophy (DMD) and a mild COVID-19 disease course. These patients were referred for CMR due to electrocardiographic and echocardiographic alterations, which did not exist before COVID-19 infection. CMR identified the presence of severe myocardial inflammation in all patients based on abnormally elevated myocardial T2 ratio, late gadolinium enhancement, native T1 mapping, T2 mapping, and extracellular volume fraction. This was paired with concurrent impairment of left ventricular function. Appropriate treatment was initiated in all cases. Two of the four patients developed episodes of ventricular tachycardia during the following 6 months, and a defibrillator was implanted. Despite the mild clinical presentation, this case series demonstrates the diagnostic strength of CMR in the diagnosis and evaluation of post-COVID-19 myocarditis and serves to increase awareness of this potential complication amongst treating physicians.
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Markousis‐Mavrogenis et al. (2023) conducted a case report in Post-COVID-19 myocarditis in Duchenne Muscular Dystrophy (n=4). Cardiovascular Magnetic Resonance (CMR) was evaluated on Presence of severe myocardial inflammation and left ventricular function impairment. Cardiovascular Magnetic Resonance identified severe myocardial inflammation and concurrent left ventricular impairment in all 4 patients with Duchenne Muscular Dystrophy following mild COVID-19.
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