Key result
Ultrasound-detected medial arterial calcification linked to ~94% greater risk of major cardiovascular and limb events.
Why the study?
Medial arterial calcification is an important marker of cardiovascular events, but its association with cardiovascular and lower-limb events when detected during ultrasound screening in type-2 diabetes needed assessment.
Does ultrasound-detected medial arterial calcification (MAC) predict cardiovascular and lower-limb events in asymptomatic patients with type-2 diabetes?
Population
1119 patients with type-2 diabetes free from CV disease
Comparison
Presence vs absence of medial arterial calcification on posterior tibial arteries
Design
Retrospective cohort study
Follow-up
5 years
Authors
Loading...
May enhance CV risk stratification in asymptomatic type 2 diabetes beyond ABI; leaves open whether detection changes management or outcomes.
Cohort (n=1,119)
Does ultrasound-detected medial arterial calcification (MAC) predict cardiovascular and lower-limb events in asymptomatic patients with type-2 diabetes?
Hazard Ratio: 1.94 (95% CI 1.23–3.08)
p-value: p=0.005
Ultrasound-detected medial arterial calcification on tibial arteries is an independent predictor of cardiovascular and lower-limb events in asymptomatic patients with type-2 diabetes, refining risk assessment even in those with normal ankle-brachial index.
Salle et al. (2023) conducted a cohort in Type-2 diabetes (n=1,119). Ultrasound-detected medial arterial calcification (MAC) vs. Absence of MAC was evaluated on Composite of major acute cardiovascular events (MACEs) and lower-limb events (MALEs) (HR 1.94, 95% CI 1.23-3.08, p=0.005). Ultrasound-detected medial arterial calcification was significantly associated with a composite of major cardiovascular and lower-limb events (HR 1.94; 95% CI 1.23-3.08; p=0.005).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: