Polymorphism of the MMP-2, MMP-9, TIMP-2 genes and the expression pattern of matrix metalloproteinases types 2 and 9 of the placenta of women with recurrent miscarriage

Expression indices of matrix metalloproteinases (MMPs) of types 2 and 9 and polymorphism of MMP-2, MMP-9 and their tissue inhibitor (TIMP-2) genes in placental tissue of women with early reproductive losses were determined. MMP-2 expression in placental tissue preparations was found to be significantly higher among women with recurrent miscarriage in the first trimester pregnancy than in women with normal pregnancy. Associations of the mutant T allele of the 735 C/T polymorphism of the MMP-2 gene and the mutant C allele of the 418 G/C polymorphism of the TIMP-2 gene with a high level of matrix MMP-2 expression were found. The level of MMP-9 expression in the placenta of women with recurrent miscarriage and with physiological pregnancy was not statistically significantly different.