Key result
Rapid IV lignocaine induces dose-dependent coronary dilatation and systolic dysfunction in a swine model.
Why the study?
The effects of lignocaine on coronary blood flow, myocardial systolic function, and high energy phosphate stores were not fully characterized in a controlled experimental setting.
Does rapid intravenous lignocaine injection alter coronary blood flow and myocardial systolic function in a swine model?
Population
14 open chest anaesthetized swine
Comparison
Rapid intravenous lignocaine injection with vs without continuous low-dose infusion pre-treatment
Design
Experimental study measuring coronary flow, myocardial function, and phosphate content
Authors
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May warrant caution interpreting lignocaine effects in swine models; leaves open human translation of coronary dilatation and systolic dysfunction.
Does rapid intravenous lignocaine injection alter coronary blood flow and myocardial systolic function in a swine model?
Rapid intravenous lignocaine causes dose-dependent coronary dilatation and systolic dysfunction in a swine model.
Perlmutter et al. (1990) studied Open chest anaesthetized swine (n=14). Lignocaine vs. No pre-treatment with low-dose continuous infusion was evaluated on Peak diastolic coronary flow and per cent wall thickening. Rapid intravenous lignocaine injection caused a dose-dependent coronary dilatation and systolic dysfunction in open chest anaesthetized swine.
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