Anti-HIV Passive Immunization in Animal Models

Antibodies constitute a powerful weapon to fight viral infections. Recent advances in the identification and characterization of broadly neutralizing antibodies (bNAbs) of HIV have reinvigorated testing of passive immunization with bNAbs to prevent HIV infection. Using monkeys or humanized mice as challenge models, passive infusion of the potent and broad bNAbs has been shown to be highly protective against HIV. This review summarizes the current state of the anti-HIV passive immunization in animal models.