Key result
A four-variable model predicts post-induction hypotension in elderly non-cardiac surgery patients with ~0.70 AUC.
Why the study?
Post-induction hypotension is prevalent in elderly surgical patients and associated with adverse outcomes, but predicting it remains challenging.
Cohort (n=938)
No
Effect estimate: AUC 0.697 (95% CI 0.635-0.759)
A novel prediction model using four clinical variables demonstrated moderate discrimination for predicting post-induction hypotension in elderly patients undergoing non-cardiac surgery.
May aid preoperative risk stratification in elderly patients; leaves open whether implementation improves outcomes.
BACKGROUNDS: Post-induction hypotension (PIH) is prevalent in elderly surgical patients and associated with adverse outcomes; however, predicting PIH remains challenging. We aimed to develop a feasible and practical PIH prediction model for elderly patients undergoing non-cardiac surgery. METHODS: In this single-center prospective cohort study, 938 elderly patients undergoing non-cardiac surgery were enrolled from December 2022 to May 2023 (n = 657 in the development cohort) and from June 2023 to August 2023 (n = 281 in the temporal validation cohort), respectively. The study outcome was the occurrence of PIH, defined as hypotension during the first 15 min after anesthesia induction or until skin incision (whichever occurred first). Predictors were determined based on LASSO and logistic regression analyses. A nomogram and a dynamic application were used for model visualization. The internal and temporal validation were performed to evaluate the discriminability, calibration and clinical utility. RESULTS: The median age was 71 years in both cohorts. The incidence of PIH was 51.6% and 50.5% in the development and validation cohorts, respectively. Cardiac function, baseline mean arterial pressure in the ward, etomidate use, and pre-induction mean arterial pressure were determined as predictors. The PIH prediction model was visualized as a nomogram and a dynamic application. The area under the receiver operating characteristic curve was 0.680 (95% confidence interval [CI]: 0.639 to 0.720) in internal validation and 0.697 (95% CI: 0.635 to 0.759) in temporal validation. The mean absolute errors were 0.012 and 0.029 for the internal and temporal validation calibration curves, respectively. The Brier score was 0.223. The decision curve analysis indicated that the model had a gain in predicting PIH. CONCLUSION: A PIH prediction model with four predictors was developed and validated for elderly patients undergoing non-cardiac surgery. This model provides a foundation for future refinements to enhance its value of assisting clinical decision-making across diverse healthcare settings. TRIAL REGISTRATION: This study was registered at the Chinese Clinical Trial Registry (ChiCTR2200066201).
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Bian et al. (2025) conducted a cohort in Post-induction hypotension (n=938). PIH prediction model (cardiac function, baseline MAP, etomidate use, pre-induction MAP) was evaluated on Prediction of post-induction hypotension (hypotension during the first 15 min after anesthesia induction or until skin incision) (AUC 0.697, 95% CI 0.635-0.759). A prediction model incorporating cardiac function, baseline MAP, etomidate use, and pre-induction MAP predicted post-induction hypotension in elderly non-cardiac surgery patients with an AUC of 0.697 in temporal validation.
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