Key result
Polycystic ovaries display intense renin and angiotensin immunostaining, linking the renin-angiotensin system to PCOD.
Why the study?
The role of the ovarian renin-angiotensin system in polycystic ovarian disease was hypothesized but not established.
Observational
The ovarian renin-angiotensin system shows altered distribution in polycystic ovarian disease, with intense expression in both theca and granulosa cells of cystic follicles, suggesting a potential role in its pathogenesis.
Authors
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Leaves open a role for ovarian RAS in PCOS pathogenesis; hypothesis-generating and should not change practice.
Palumbo et al. (1993) conducted an observational in Polycystic ovarian disease (PCOD). Polycystic ovarian disease vs. Normal ovaries was evaluated on Immunohistochemical distribution of renin and angiotensin. Polycystic ovaries displayed intense immunostaining for renin and angiotensin in both theca and granulosa cells of large cystic follicles, suggesting a link between the renin-angiotensin system and PCOD.
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