Key result
Cyanidin-3-glucoside cuts platelet P-selectin expression by ~18% in mice fed a high-fat diet.
Why the study?
Direct evidence of the action of Cyanidin-3-glucoside on platelet granule secretion in purified platelets from in vivo assays was still poor.
Does dietary supplementation of Cyanidin-3-glucoside reduce platelet granule release in mice fed high-fat diets?
Does dietary supplementation of Cyanidin-3-glucoside reduce platelet granule release in mice fed high-fat diets?
Effect estimate: 18.3% reduction
p-value: p=<0.05
Cyanidin-3-glucoside supplementation may protect against thrombosis and cardiovascular diseases by inhibiting platelet granule release in vivo.
Platelet granule release is considered an important target for preventing and treating cardiovascular diseases (CVDs). Cyanidin-3-glucoside (Cy-3-g) is a predominant bioactive anthocyanin compound in many edible plants and has been reported to be protective against CVDs by attenuating platelet dysfunction. However, direct evidence of the action of Cy-3-g on platelet granule secretion in purified platelets from in vivo assays is still poor. In the present study, we demonstrated that dietary supplementation of purified Cy-3-g reduces serum lipid levels and facilitates down-regulation of the platelet granule release of substances such as P-selectin, CD40L, 5-HT, RANTES and TGF-β1 in gel-filtered platelets, in addition to attenuating serum PF4 and β-TG levels in mice fed high-fat diets. These results provide evidence that Cy-3-g protects against thrombosis and CVDs by inhibiting purified platelet granule release in vivo.
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Zhou et al. (2017) studied High-fat diet-induced platelet dysfunction (n=60). Cyanidin-3-glucoside (Cy-3-g) vs. High-fat diet (HFD) alone was evaluated on P-selectin expression in gel-filtered platelets (18.3% reduction, p=<0.05). Dietary supplementation with cyanidin-3-glucoside significantly decreased the expression of P-selectin by 18.3% and CD40L by 23.9% in platelets of mice fed a high-fat diet.
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