Key result
PCOS and endometrial cancer show decreased endometrial monoacylglycerol 24:0 and capric acid versus controls.
Why the study?
Women with PCOS have an increased risk of endometrial cancer, but the underlying molecular mechanisms and the potential role of lipid metabolism derangements remain unclear.
Are there shared lipidomic biomarkers in women with polycystic ovary syndrome and endometrial cancer compared to controls?
Cross-Sectional (n=102)
No
Are there shared lipidomic biomarkers in women with polycystic ovary syndrome and endometrial cancer compared to controls?
PCOS and endometrial cancer may share specific lipidomic derangements, such as decreased monoacylglycerol 24:0 and capric acid in endometrial tissue, suggesting a potential molecular link.
May link PCOS to endometrial cancer via shared lipid changes; hypothesis-generating and requires prospective validation before clinical use.
Women with polycystic ovary syndrome (PCOS) are more likely to develop endometrial cancer (EC). The molecular mechanisms which increase the risk of EC in PCOS are unclear. Derangements in lipid metabolism are associated with EC, but there have been no studies, investigating if this might increase the risk of EC in PCOS. This was a cross-sectional study of 102 women in three groups of 34 (PCOS, EC and controls) at Nottingham University Hospital, UK. All participants had clinical assessments, followed by obtaining plasma and endometrial tissue samples. Lipidomic analyses were performed using liquid chromatography (LC) coupled with high resolution mass spectrometry (HRMS) and the obtained lipid datasets were screened using standard software and databases. Using multivariate data analysis, there were no common markers found for EC and PCOS. However, on univariate analyses, both PCOS and EC endometrial tissue samples showed a significant decrease in monoacylglycerol 24:0 and capric acid compared to controls. Further studies are required to validate these findings and investigate the potential role of monoacylglycerol 24:0 and capric acid in the link between PCOS with EC.
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Shafiee et al. (2020) conducted a cross-sectional in Polycystic ovary syndrome and endometrial cancer (n=102). Polycystic ovary syndrome and endometrial cancer vs. Controls was evaluated on Common lipidomic markers for endometrial cancer and PCOS. Endometrial tissue samples from women with PCOS and endometrial cancer showed a significant decrease in monoacylglycerol 24:0 and capric acid compared to controls.
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