Key result
Rett syndrome is linked to longer QTc, with QT prolongation affecting ~26% of girls.
Why the study?
Prolonged QT interval has been described in Rett syndrome, but its prevalence and association with cardiac tachyarrhythmias needed prospective investigation.
Do girls with Rett syndrome have prolonged QT intervals compared to healthy controls?
Population
34 girls with Rett syndrome
Comparison
Patients with Rett syndrome vs healthy controls of similar age
Design
Prospective cohort study with electrocardiography and 24 hour Holter monitoring
Authors
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Rett syndrome was associated with QT prolongation; hypothesis-generating for arrhythmia risk and requires prospective validation.
Cohort (n=34)
Do girls with Rett syndrome have prolonged QT intervals compared to healthy controls?
Girls with Rett syndrome have a significantly higher prevalence of prolonged QT intervals compared to healthy controls, highlighting the need for cardiac screening in this population.
Ellaway et al. (1999) conducted a cohort in Rett syndrome (n=34). Rett syndrome vs. Healthy controls was evaluated on Corrected QT value. Girls with Rett syndrome had significantly longer corrected QT values compared to healthy controls, with prolonged QT observed in 9 of 34 patients.
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