Key result
Essential hypertension is linked to increased hsa_circ_0124782 and decreased hsa_circ_0131618 and hsa_circ_0127342 blood levels.
Why the study?
Carotid plaque is a crucial precursor for cardiovascular events in essential hypertension, making the identification of risk factors and pathogenesis vital.
Observational (n=192)
p-value: p=< .05
Specific circular RNAs (hsa_circ_0124782, hsa_circ_0131618, and hsa_circ_0127342) are differentially expressed in patients with essential hypertension and carotid plaque, suggesting their potential as biomarkers for target organ damage.
These circRNAs may mark carotid plaque in hypertension; hypothesis-generating for biomarker validation in prospective cohorts.
Background As one of the essential hypertension (EH)-mediated target organ damage, carotid plaque is a crucial subclinical precursor for cardiovascular events. Therefore, it is vital to identify the risk factors and pathogenesis for EH with carotid plaque.Methods Based on our previous microarray analysis, we selected four circRNAs as the candidate circRNAs and detected their expression levels in blood of 192 subjects (64 healthy controls, 64 EH patients, and 64 EH patients with carotid plaque) by qRT-PCR analysis. The regulatory mechanism of circRNAs involved in carotid plaque was predicted by bioinformatics analysis.Results The level of hsa_circ_0124782 increased significantly and the levels of hsa_circ_0131618 and hsa_circ_0127342 decreased significantly in the EH group and EH with carotid plaque group compared with the control group (P < .05). Functional enrichment analysis showed that three circRNAs might be implicated in pathogenesis for carotid plaque.Conclusion Our study revealed the relationship between three circRNAs and carotid plaque, suggesting that they may serve as potential biomarkers for EH with carotid plaque.
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Qian et al. (2023) conducted an observational in Essential Hypertension with Carotid Plaque (n=192). Circular RNAs levels (hsa_circ_0124782, hsa_circ_0131618, hsa_circ_0127342) vs. Healthy controls was evaluated on Expression levels of circRNAs in blood (p=< .05). Blood levels of hsa_circ_0124782 were significantly increased, while hsa_circ_0131618 and hsa_circ_0127342 were decreased in essential hypertension patients with and without carotid plaque (P<.05).
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