Key result
Lumped parameter models identify specific compliances and resistances as key indicators of declining Fontan physiology.
Why the study?
Clinical and mathematical definitions of Fontan failure are lacking, and understanding of parameters indicative of declining physiologies is needed.
Lumped parameter models identified key physiological parameters that may help define and understand failing Fontan circulations.
Answers are grounded in this paper and cite their sources.
May inform failing Fontan characterization; leaves open validation for outcome prediction or interventions.
Fontan circulations are surgical strategies to treat infants born with single ventricle physiology. Clinical and mathematical definitions of Fontan failure are lacking, and understanding is needed of parameters indicative of declining physiologies. Our objective is to develop lumped parameter models of two-ventricle and single-ventricle circulations. These models, their mathematical formulations and a proof of existence of periodic solutions are presented. Sensitivity analyses are performed to identify key parameters. Systemic venous and systolic left ventricular compliances and systemic capillary and pulmonary venous resistances are identified as key parameters. Our models serve as a framework to study the differences between two-ventricle and single-ventricle physiologies and healthy and failing Fontan circulations.
No takes yet. Share an insight, caveat, or question.
Doyle et al. (2021) studied Single ventricle physiology / Fontan circulation. Lumped parameter models was evaluated on Identification of key parameters indicative of declining physiologies. Lumped parameter models identified systemic venous and systolic left ventricular compliances and systemic capillary and pulmonary venous resistances as key parameters in Fontan circulations.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: