Key result
A computational model of the Fontan circulation in a two-year-old achieved an average relative error of 0.8% against clinical targets, requiring modification of only 12 parameters from normal.
Why the study?
Can a modified lumped parameter model accurately simulate the hemodynamics of a normal two-year-old and a two-year-old with HLHS after a Fontan operation?
Population
Computational model of a normal two-year-old and a two-year-old patient with hypoplastic left heart syndrome…
Comparison
Modified lumped parameter multicompartment model… vs Normal two-year-old circulatory system model
Design
Preclinical
Authors
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May guide Fontan simulation studies; leaves open prospective human validation before clinical use.
Can a modified lumped parameter model accurately simulate the hemodynamics of a normal two-year-old and a two-year-old with HLHS after a Fontan operation?
Absolute Event Rate: 0.8% vs 0.9%
A multicompartment computational model can accurately simulate clinically plausible hemodynamics in both normal and Fontan circulatory systems, demonstrating that the impact of total cavopulmonary connection resistance on cardiac output is significantly affected by ventricular elastance.
Watrous et al. (2014) studied Hypoplastic left heart syndrome (HLHS) following Fontan operation. Computational model of Fontan operation vs. Computational model of normal two-year-old was evaluated on Average relative error against target values for clinically realistic hemodynamic variables. A computational model of the Fontan circulation in a two-year-old achieved an average relative error of 0.8% against clinical targets, requiring modification of only 12 parameters from normal.
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